By Chuang Lu, Albert P. Li
The technology and utilized ways of enzyme inhibition in drug discovery and improvement
Offering a distinct technique that comes with either the pharmacologic and pharmaco-kinetic facets of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the clinical strategies and experimental techniques with regards to enzyme inhibition as utilized in drug discovery and drug development.
With chapters written via over fifty prime specialists of their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology through realizing the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The publication discusses:
The drug discovery approach, together with drug discovery procedure, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safeguard biomarker assessment
The manipulations of drug metabolizing enzymes and transporters in addition to the adverse effects, equivalent to drug–drug interactions
The inhibition of a number of significant drug objective pathways, resembling the GPCR pathway, the NFkB pathway, and the ion channel pathway
Through this targeted, single-source reference at the basics of drug discovery and improvement, researchers in drug metabolism and pharmacokinetics (DMPK) will research and take pleasure in aim biology in drug discovery; discovery biologists and medicinal chemists also will expand their knowing of DMPK.