By Brad Reisfeld, Arthur N. Mayeno
Rapid advances in desktop technological know-how, biology, chemistry, and different disciplines are allowing strong new computational instruments and types for toxicology and pharmacology. those computational instruments carry super promise for advancing technological know-how, from streamlining drug efficacy and defense trying out, to expanding the potency and effectiveness of threat overview for environmental chemical compounds. Computational Toxicology offers biomedical and quantitative scientists with crucial heritage, context, examples, beneficial tips, and an outline of present advancements within the box. Divided into 4 sections, Volume I covers a big selection of methodologies and issues. commencing with an advent to the sphere of computational toxicology and its present and capability functions, the quantity keeps with ’best practices’ in mathematical and computational modeling, through chemoinformatics and using computational concepts and databases to foretell chemical houses and toxicity, to boot as an evaluation of molecular dynamics. the ultimate part is a compilation of the most important parts and major methods utilized in pharmacokinetic and pharmacodynamic modeling, together with the modeling of absorption, compartment and non-compartmental modeling, physiologically established pharmacokinetic modeling, interspecies extrapolation, and inhabitants results. Written within the winning Methods in Molecular Biology™ sequence structure the place attainable, chapters comprise introductions to their respective themes, lists of the fabrics and software program instruments used, equipment, and notes on troubleshooting.
Authoritative and simply available, Computational Toxicology will enable influenced readers to take part during this interesting box and adopt a variety of real looking difficulties of interest.